Thermo Fisher Scientific ATP1A3 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC-P): 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence: DKKDDKDSPK KNKGKERRDL DDLKKE

Target Information

The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA).

The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit (alpha subunit) and an associated smaller glycoprotein (beta subunit). There are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1, beta 2), encoded by two multigene families. These isoforms exhibit tissue-specific and developmental expression patterns. The alpha-3 subunit is found in neuronal, skeletal, and cardiac muscle, lung, and stomach tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.