Thermo Fisher Scientific MKP-1 Polyclonal Antibody
MKP-1 단백질을 인식하는 Thermo Fisher Scientific의 고품질 다클론 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 인간 및 설치류 반응성이 검증되었습니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, 안정적인 TBS 버퍼에 보존됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 8 µg/mL
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (SYLQSPITTSPSC) corresponding to the C-terminus amino acids of DUSP1 (aa 355–367) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10986429 |
Product Specific Information
- Predicted to react with bovine and canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.
It encodes a protein similar to non-receptor-type protein-tyrosine phosphatases and shows significant sequence similarity to the Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.
The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by dephosphorylating both phosphothreonine and phosphotyrosine residues.
It also suppresses MAP kinase activation by oncogenic ras in Xenopus oocyte extracts, suggesting an important role in stress response and negative regulation of cellular proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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