Thermo Fisher Scientific Nitro-Alpha-synuclein (Tyr39) Polyclonal Antibody
Rabbit polyclonal antibody specific for Nitro-Alpha-synuclein (Tyr39). Validated for WB and IHC(P) applications. Recognizes human, mouse, and rat targets. Supplied as liquid form, purified by Protein A, for research use only.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic nitrylpeptide derived from human Alpha-synuclein around nitration site of Tyr39 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, indicating involvement in signaling pathways. Mutations in the SNCA gene, encoding alpha-synuclein, are linked to Parkinson’s disease pathogenesis. Alpha-synuclein peptides are major components of amyloid plaques found in Alzheimer’s disease brains. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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