Thermo Fisher Scientific SSTR5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:4,000-1:6,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

-

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2500

-

Immunocytochemistry (ICC/IF)

1:5,000

-

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues Q(344) E A T R P A H R A A A N G L M Q T S K L(364) of human SSTR5. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SSTR5,uniProtId:P35346-1,ncbiNodeId:9606,antigenRange:345-364,antigenLength:364,antigenImageFileName:PA3-112_SSTR5_P35346-1_Rabbit.svg,antigenImageFileNamePDP:PA3-112_SSTR5_P35346-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2271110

Product Specific Information

PA3-112 detects the Somatostatin Receptor 5 in human samples.

PA3-112 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR5 transfected HEK-293 cells this antibody detects a ~54-63 kDa protein representing SSTR5.

The PA3-112 immunogen is a synthetic peptide corresponding to residues Q(344) E A T P P A H R A A A N G L M Q T S K L(364) of human SSTR5.

Target Information

Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. Till date, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364A.A protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.