Thermo Fisher Scientific Phospho-INSR (Tyr1361) Polyclonal Antibody
Phospho-INSR (Tyr1361) 폴리클로날 항체로, 인산화된 INSR Tyr1361을 특이적으로 검출합니다. Western blot, IHC, ICC/IF에 적합하며 사람, 생쥐, 랫트에서 반응합니다. PBS 기반 용액으로 50% 글리세롤 포함, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human INSR (Accession P06213), corresponding to amino acid residues around phosphorylated Tyr1361 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816227 |
Product Specific Information
This antibody detects endogenous levels of IR only when phosphorylated at Tyrosine 1361.
Target Information
INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes, and IGF-1R defects may also cause some forms of growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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