Thermo Fisher Scientific GNA13 Polyclonal Antibody
Thermo Fisher Scientific의 GNA13 폴리클로날 항체는 인간, 마우스, 랫트 시료에 반응하며 Western blot과 IHC(파라핀 절편)에 적합합니다. 항원 친화 크로마토그래피로 정제된 고품질 항체로, RhoA 신호전달 연구에 유용합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human G protein alpha 13 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.29 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735792 |
Product Specific Information
- Positive Control: 293T, A431, HeLa, HepG2
- Predicted Reactivity: Mouse (95%), Rat (95%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Guanine nucleotide-binding proteins (G proteins) act as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452).
They activate effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF, ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866).
GNA13-dependent Rho signaling regulates transcription factor AP-1 and promotes tumor cell invasion and metastasis via the RhoA/ROCK pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452).
It also inhibits CDH1-mediated cell adhesion independently of Rho activation (PubMed:11976333).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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