Thermo Fisher Scientific SESN1 Polyclonal Antibody, FITC
SESN1 단백질을 인식하는 FITC 결합 폴리클로날 항체로, Western blot, ELISA, IP에 사용 가능. 인간, 마우스, 랫트 반응성. p53 경로 및 산화 스트레스 연구에 유용. -20°C 어두운 곳에 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 of human SESN1 protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase (AMPK), which results in the inhibition of the mammalian target of rapamycin (mTOR) protein. It also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins. Expression of this gene is a potential marker for radiation exposure. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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