Thermo Fisher Scientific PSMA1 Monoclonal Antibody (S3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein Sequence:

MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK RAQSELAAHQ 
KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD RPLPVSRLVS LIGSKTQIPT 
QRYGRRPYGV GLLIAGYDDM GPHIFQTCPS ANYFDCRAMS IGARSQSART YLERHMSEFM 
ECNLNELVKH GLRALRETLP AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLEGLEERP 
QRKAQPAQPA DEPAEKADEP MEH

Target Information

Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most cytosolic and nuclear proteins in eukaryotic cells, while others are degraded via the vacuolar pathway (endosomes, lysosomes, ER).

The 26S proteasome is an ATP-dependent, multisubunit complex (~2.5 MDa) composed of a 20S proteolytic core capped by one or two 19S regulatory subunits. The 19S complex recognizes ubiquitinated proteins and facilitates their unfolding and translocation into the 20S core.

Defects in the ubiquitin-proteasome pathway are linked to various genetic disorders, including cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.