
Thermo Fisher Scientific TMEM88 Polyclonal Antibody
Rabbit polyclonal antibody targeting human TMEM88 protein for Wnt signaling research. Unconjugated form with 0.3 mg/mL concentration. Suitable for research use only; store at 4°C short term or -20°C long term.
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Thermo Fisher Scientific TMEM88 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TMEM88 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648736 |
Product Specific Information
- Immunogen sequence: ADVPGAQRAV PGDGPEPRDP LDCWACAVLV TAQNLLVAA
- Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 77%
Target Information
Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail binds the PDZ domain of Dishevelled (Dvl), a key component in Wnt signaling pathways.
TMEM88 attenuates Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner. Knockdown of TMEM88 by RNAi increases Wnt activity, suggesting that TMEM88 regulates Wnt signaling in a context-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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