Thermo Fisher Scientific NLRP3 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total NLRP3.

Target Information

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif.
The protein interacts with apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex.
This complex functions as an upstream activator of NF-kappaB signaling, playing a role in regulation of inflammation, immune response, and apoptosis.
Mutations in this gene are associated with familial cold autoinflammatory syndrome and neonatal-onset multisystem inflammatory disease.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Alternative 5' UTR structures are suggested, but insufficient evidence exists to determine biological validity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-115660_NLRP3_Q96P20-1_Rabbit.svg, PA5-115660_NLRP3_Q96P20-1_Rabbit_PDP.jpeg)