Thermo Fisher Scientific TGM2 Monoclonal Antibody (CUB 7402), Biotin

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

View 34 publications 34 publications

Immunohistochemistry (IHC)

-

View 20 publications 20 publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

Immunocytochemistry (ICC/IF)

-

View 9 publications 9 publications

ELISA (ELISA)

-

View 4 publications 4 publications

Immunoprecipitation (IP)

2 µg/mL

View 4 publications 4 publications

Neutralization (Neu)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Dog, Guinea pig, Human, Rabbit

Published species

Dog, Hamster, Human, Mouse, Non-human primate, Pig, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

CUB 7402

Immunogen

Purified guinea pig liver TGase II if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TGM2,uniProtId:P08587-1,ncbiNodeId:10141,antigenRange:1-690,antigenLength:690,antigenImageFileName:MA5-12736_TGM2_P08587-1_House_mouse.svg,antigenImageFileNamePDP:MA5-12736_TGM2_P08587-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Biotin Biotin Biotin

View additional formats

• Unconjugated
• Request custom conjugation

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10985720

Product Specific Information

MA5-12736 targets Transglutaminase II in IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Guinea Pig, Human, and Rabbit samples.

The MA5-12736 immunogen is purified guinea pig liver TGase II.

Target Information

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer`s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.