Thermo Fisher Scientific Pannexin 3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent
• View 5 publications

Immunohistochemistry (IHC)

• Tested Dilution: —
• View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: Assay-dependent
• View 1 publication

Product Specifications

Target Information

Pannexins constitute a new family of gap junction-type proteins. They are highly conserved across species such as worms, mollusks, insects, and mammals. Pannexins are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop, and intracellular N- and C-termini.

Pannexin 1 and 2 are molecular components of neuronal gap junctions (electrical synapses) that form connections between principal cells in the hippocampus. Functional expression in paired Xenopus oocytes indicates that pannexins can form communicating junctions. Additionally, Pannexin 1 can form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane.

Pannexin 1 and 3 are glycoproteins with distinct cell surface distribution profiles and life cycle dynamics compared to connexin 43. Pannexin 3 expression is prevalent in skin and cartilage. In transiently expressing cells, both pannexin 1 and 3 form functional cell surface channels rather than intercellular channels. Suggested roles include involvement in ischemic neuronal death, schizophrenia, inflammation, and tumor suppression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)