Thermo Fisher Scientific Pannexin 3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 5 publications 5 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from the C-terminal region of the mouse and rat Pannexin 3 protein if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Pannexin 3,uniProtId:Q8CEG0-1,ncbiNodeId:10090,antigenRange:392,antigenLength:392,antigenImageFileName:433270_Pannexin_3_Q8CEG0-1_Rabbit.svg,antigenImageFileNamePDP:433270_Pannexin_3_Q8CEG0-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2532206

Target Information

Pannexins constitute a new family of gap junction type proteins. They are highly conserved in worms, mollusks, insects and mammals and are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop and intracellular N- and C-termini. Besides the connexin proteins, Pannexin 1 and 2 seem to be molecular components of neuronal gap junctions (electrical synapses) that are thought to form connections between principal cells in the hippocampus. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions. In addition to forming gap junction channels in paired oocytes, Pannexin 1 can also form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane. Pannexin 1 and 3 are both glycoproteins with a cell surface distribution profile and life cycle dynamics distinct from connexin 43. Pannexin 3 expression was prevalent in skin and cartilage. In transiently expressing cells both pannexin 1 and 3 were incapable of forming intercellular channels but assembled into functional cell surface channels. Suggested roles in the ischemic death of neurons, schizophrenia, inflammation and tumor suppression have drawn attention for properties and cellular functions of pannexins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.