Thermo Fisher Scientific RYBP Monoclonal Antibody (OTI2F6), TrueMAB
RYBP 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot에 적합. 인간 단백질과 반응하며, 고순도 친화 크로마토그래피로 정제됨. PBS/BSA/glycerol buffer에 보존되어 안정성 우수. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F6 |
| Immunogen | Full length human recombinant protein of human RYBP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RYBP is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for maintaining transcriptional repression of genes such as Hox during development. This complex mediates monoubiquitination of histone H2A at Lys-119, resulting in heritable chromatin modification. RYBP also participates in X-chromosome silencing, TP53 regulation, and apoptosis control through ubiquitin-mediated pathways. It may act as a transcriptional repressor and DNA-binding protein, potentially involved in tumor growth repression and metastasis inhibition in breast cancer by downregulating SRRM3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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