Thermo Fisher Scientific GOLPH3 Polyclonal Antibody
GOLPH3 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. Human 및 Mouse 시료에 반응하며, 비결합형 액상 형태로 제공됩니다. 암모늄 황산 침전으로 정제되었으며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DLATKRVRQLLDLD (aa 262–275) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933181 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but has also been reported as a mitochondrial protein regulating mitochondrial mass through cardiolipin control. It is implicated in the TOR signaling pathway, where overexpression enhances anchorage-independent growth, cell proliferation, and S6 Kinase activity in response to EGF. Increased AKT phosphorylation is observed in GOLPH3-transfected cells, while GOLPH3 siRNA treatment reduces these effects. These findings suggest GOLPH3 functions as a bona fide oncogene and may be a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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