Thermo Fisher Scientific GATSL2 Polyclonal Antibody
Human GATSL2 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:200-1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체. GATOR 복합체를 통한 TORC1 신호 억제 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GATSL2 (Recombinant protein control fragment: Product #RP-104512) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641887 |
Product Specific Information
- Immunogen sequence: FDHALVPEEN INGVISALKV SQAEKH
- Antigen sequence identity: Mouse – 88%, Rat – 88%
Target Information
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex.
As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1.
Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2, which can in turn activate mTORC1 and the TORC1 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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