Thermo Fisher Scientific VEGF Monoclonal Antibody (OTI15C8), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

VEGF (Vascular Endothelial Growth Factor) is a 45 kDa homodimeric, disulfide-linked glycoprotein crucial for angiogenesis, tumor progression, and metastasis.
It promotes endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability.
The VEGF family includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PlGF.
VEGF interacts with tyrosine kinase receptors FLT1 (VEGFR-1) and FLK1/KDR (VEGFR-2), primarily expressed on endothelial cells.
A soluble form, sFLT1, binds VEGF with high affinity, inhibiting angiogenesis.
Elevated VEGF levels are associated with POEMS syndrome (Crow-Fukase syndrome), affecting multiple organs.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.