Thermo Fisher Scientific MAP2K1 Monoclonal Antibody (OTI5D3), TrueMAB
MAP2K1(MEK1) 단백질을 인식하는 mouse monoclonal antibody로, WB, IHC, ICC 등 다양한 응용 가능. 고순도 Affinity chromatography 정제, 1 mg/mL 농도 액상 형태. 인간 단백질에 반응하며 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:8000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D3 |
| Immunogen | Full length human recombinant protein of human MAP2K1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase functioning in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation.
MAP2K1 is activated by various growth factors, cytokines, membrane depolarization, and calcium influx.
Mek1 activation occurs via phosphorylation of serine 218 and 222 residues by Raf1.
It is involved in signaling for stress response, apoptosis, and proliferation induced by cytokines.
Mutations in MAP2K1 can lead to cardiofaciocutaneous syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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