Thermo Fisher Scientific CHFR Polyclonal Antibody
CHFR 단백질을 표적하는 Goat Polyclonal 항체로, Western blot 및 IHC(P) 실험에 적합. 인간에 반응하며, 다른 종에서도 예측 반응. 액상 형태, 0.5 mg/mL 농도, TBS buffer 및 sodium azide 포함. 연구용 전용 제품.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (KFNHICEQTRFKN) corresponding to the C-terminus amino acids of CHFR (aa 652-664) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_11000351 |
Product Specific Information
- Predicted to react with bovine, mouse, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons.
Acts in early prophase before chromosome condensation, when centrosomes move apart along the periphery of the nucleus.
Involved in signaling mitotic stress caused by microtubule poisons through Lys-48-linked ubiquitination of target proteins, leading to proteasomal degradation.
Promotes ubiquitination and degradation of AURKA and PLK1.
Acts as a tumor suppressor by mediating polyubiquitination of HDAC1, leading to its degradation.
May also promote formation of Lys-63-linked polyubiquitin chains and functions with UBC13-MMS2 (UBE2N-UBE2V2) heterodimer.
Substrates polyubiquitinated at Lys-63 are involved in cellular stress signaling rather than degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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