Thermo Fisher Scientific Calnexin Polyclonal Antibody
Rabbit polyclonal antibody targeting Calnexin for detection of endogenous protein levels. Suitable for WB, IHC(P), and ICC/IF applications. Affinity purified, liquid form, 1 mg/mL concentration. Stored at -20°C in PBS with 50% glycerol.
- 판매단위
- pk
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Thermo Fisher Scientific Calnexin Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CANX (Accession P27824), corresponding to amino acid residues E557–E592 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899569 |
Product Specific Information
Antibody detects endogenous levels of total Calnexin.
Target Information
Calnexin, also referred to as IP90, p88, and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER).
Many ER-resident proteins act as molecular chaperones, assisting in proper folding and assembly of polypeptides.
Calnexin associates with MHC class I heavy chains and partial complexes of T cell receptors and B cell membrane immunoglobulins, but not with completed receptor complexes.
It functions as a chaperone, retaining incompletely or improperly folded proteins in the ER.
Soluble ER resident proteins often contain the KDEL sequence for ER retention, while integral membrane proteins like Calnexin lack KDEL but possess positively charged cytosolic residues ensuring retention.
Calnexin structure includes:
- ER luminal domain (461 amino acids)
- Transmembrane segment (22 amino acids)
- Cytoplasmic tail (89 amino acids)
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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