Thermo Fisher Scientific EPCAM Monoclonal Antibody (OTI1C1), TrueMAB
인간 EpCAM 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용.
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Thermo Fisher Scientific EPCAM Monoclonal Antibody (OTI1C1), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C1 |
| Immunogen | Full-length human recombinant protein of EPCAM produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Ep-CAM (epithelial adhesion molecule, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial tissues. It functions as a calcium-independent cell adhesion molecule and influences cell cycle, proliferation, and metabolism through activation of proto-oncogene c-myc and cyclins A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated interactions, affecting epithelial differentiation and growth. Overexpression of Ep-CAM correlates with enhanced epithelial proliferation and is common in human carcinomas, serving as a marker for epithelial lineage tumors.
Ep-CAM is expressed on basolateral surfaces of most simple epithelia and various carcinoma types, and can distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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