Thermo Fisher Scientific RAPGEF5 Polyclonal Antibody
RAPGEF5 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, IHC(P)에서 1:200–1:500 희석으로 사용 가능. 인간 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS 기반 버퍼에 40% 글리세롤 포함, 4°C 또는 -20°C 보관 권장.
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- PA563494
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- pk
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RAPGEF5. Recombinant protein control fragment (Product #RP-103310) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles). |
| Shipping conditions | Wet ice |
| RRID | AB_2646311 |
Product Specific Information
Immunogen sequence:
EEDLALVAIT FSGEKHELQP NDLVISKSLE ASGRIYVYRK DLADTLNPFA ENEESQQRSM RILGMNTWDL
Highest antigen sequence identity to orthologs:
- Mouse: 96%
- Rat: 96%
Target Information
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches cycling between inactive GDP- and active GTP-bound states.
Guanine nucleotide exchange factors (GEFs), such as Repac (RAPGEF5), act as RAS activators by promoting GTP acquisition to maintain the active state.
RAPGEF5 is a 580 amino acid protein expressed mainly in brain and testis, with weaker expression in heart, placenta, lung, pancreas, and small intestine.
It exists as two alternatively spliced isoforms and is conserved in cow, mouse, and rat.
The gene encoding RAPGEF5 maps to human chromosome 7p15.3, a region associated with positive response to erlotinib therapy in non-small-cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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