Thermo Fisher Scientific PLEKHG6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PLEKHG6. Recombinant protein control fragment (Product #RP-97628). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PLEKHG6,uniProtId:Q3KR16-1,ncbiNodeId:9606,antigenRange:198-292,antigenLength:790,antigenImageFileName:PA5-59578_PLEKHG6_Q3KR16-1_Rabbit.svg,antigenImageFileNamePDP:PA5-59578_PLEKHG6_Q3KR16-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645659

Product Specific Information

Immunogen sequence: GLLMEVSAET LFGNVPSLIR THRSFWDEVL GPTLEETRAS GQPLDPIGLQ SGFLTFGQRF HPYVQYCLRV KQTMAYAREQ QETNPLFHAF VQWCE

Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 83%.

Target Information

PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.