Thermo Fisher Scientific CD28 Monoclonal Antibody (JJ319), Biotin
Flow Cytometry용 Rat CD28 인식 Mouse IgG1 단클론 항체로 Biotin 결합 형태. 높은 특이성과 안정성 제공. Protein G로 정제되어 0.1 mg/mL 농도로 PBS/BSA buffer에 보존. 단기 4°C, 장기 -20°C 저장 권장.
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Thermo Fisher Scientific CD28 Monoclonal Antibody (JJ319), Biotin
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1.0 µg/1x10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | JJ319 |
| Immunogen | Rat CD28 transfected A20J cells |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538859 |
Additional Formats
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein. It belongs to the immunoglobulin superfamily and is constitutively expressed on most peripheral blood T lymphocytes. CD28 acts as a critical T cell costimulatory receptor, providing the second activation signal via binding with CD80 and CD86 on antigen-presenting cells. It prevents T cells from entering an anergic or apoptotic state. In murine lymphoid organs and blood, all CD4+ and CD8+ T cells express CD28. Expression is highest on immature thymocytes and decreases as cells mature. CD28 dysfunction is associated with diseases such as mycosis fungoides and Sezary's Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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