Thermo Fisher Scientific S100B Monoclonal Antibody (2A10)
인간 S100B 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot, ICC/IF, ELISA에 최적화. Affinity chromatography로 정제된 액상 형태이며 PBS(pH 7.4)에 보존제 없이 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A10 |
| Immunogen | S100B (NP_006263.1, 1–92 a.a) full-length recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEVVDKVMET LDNDGDGECD FQEFMAFVAM VTTACHEFFE HE
Target Information
S100B is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. These proteins are localized in the cytoplasm and/or nucleus of various cell types and are involved in regulating cellular processes such as cell cycle progression and differentiation.
S100B may function in neurite extension, melanoma cell proliferation, stimulation of Ca²⁺ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly.
Chromosomal rearrangements and altered expression of this gene have been implicated in several diseases, including Alzheimer’s disease, Down’s syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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