Thermo Fisher Scientific CD33 Monoclonal Antibody (OTI1G10), TrueMAB
CD33 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot, ICC/IF, Flow cytometry 등 다양한 연구용 응용에 적합. 인간 시료에 반응하며, 고순도 액상 형태로 제공. CD33 관련 백혈병 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G10 |
| Immunogen | Full length human recombinant protein of human CD33 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules capable of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signaling assemblies. These ITIMs are also involved in ubiquitin-mediated removal of the receptor from the cell surface.
CD33 is expressed on cells of myelomonocytic lineage and binds sialic acid residues in N- and O-glycans on cell surfaces. It is a therapeutic target for acute myeloid leukemia and is found on granulocyte and macrophage precursors in bone marrow, but not on pluripotent stem cells. CD33 is also expressed on peripheral monocytes and serves as a useful marker for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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