Thermo Fisher Scientific Factor XIII B Polyclonal Antibody

Thermo Fisher Scientific Factor XIII B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, identical to those of plasma origin. Upon activation by thrombin cleavage and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme factor XIIIa, which acts as a transglutaminase to catalyze crosslinking between fibrin molecules, stabilizing the fibrin clot.

Factor XIII deficiency is classified into two categories:

• Type I deficiency: lack of both A and B subunits
• Type II deficiency: lack of A subunit alone

These defects may lead to lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.