Thermo Fisher Scientific HOXB7 Monoclonal Antibody (4A3)
HOXB7 단백질을 인식하는 Thermo Fisher Scientific의 Mouse IgG1 단일클론 항체입니다. Western blot과 ELISA에 적합하며, 인간 시료에 반응합니다. Affinity chromatography로 정제된 액상 형태로, PBS 버퍼에 보존제가 포함되지 않습니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A3 |
| Immunogen | HOXB7 (NP_004493, 55–120 a.a) partial recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MQGLYPGGGG MAGQSAAGVY AAGYGLEPSS FNMHCAPFEQ NLSGVCPGDS AKAAGAKEQR DSDLAA
Target Information
The homeobox genes encode transcription factors that regulate developmental processes such as body patterning and organogenesis. The mammalian HOX gene complex consists of 39 genes located on 4 linkage groups (clusters) dispersed over 4 chromosomes (HOXA, HOXB, HOXC, and HOXD).
HOXB7 is expressed in most malignant T-cell lines and CD4-positive peripheral blood cells, and is constitutively expressed in both melanoma primary lesions and cell lines. HOXB7 binds to and transactivates bFGF in melanoma cell lines, but SkBr3 breast adenocarcinoma is negative for the expression of both HOXB7 and bFGF genes. HOXB7 may be a key activator of tumor-associated neoangiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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