Thermo Fisher Scientific HOXB7 Monoclonal Antibody (4A3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.03 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

4A3

Immunogen

HOXB7 (NP_004493, 55 a.a. approximately 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HOXB7,uniProtId:P09629-1,ncbiNodeId:9606,antigenRange:55-120,antigenLength:217,antigenImageFileName:H00003217-M02_HOXB7_P09629-1_House_mouse.svg,antigenImageFileNamePDP:H00003217-M02_HOXB7_P09629-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MQGLYPGGGG MAGQSAAGVY AAGYGLEPSS FNMHCAPFEQ NLSGVCPGDS AKAAGAKEQR DSDLAA

Target Information

The homeobox genes encode transcription factors that regulate developmental processes such as body patterning and organogenesis. The mammalian HOX gene complex consists of 39 genes that are located on 4 linkage groups (clusters), dispersed over 4 chromosomes (HOXA, HOXB, HOXC and HOXD). HOXB7 is expressed in most malignant T-cell lines and CD4-positive peripheral blood cells, and is constitutively expressed in both melanoma primary lesions and cell lines. HOXB7 binds to and transactivates bFGF in melanoma cell lines but SkBr3 breast adenocarcinoma is negative for the expression of both HOXB7 and bFGF genes. HOXB7 may be a key activator of tumor-associated neoangiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.