Thermo Fisher Scientific CRMP1 Polyclonal Antibody
CRMP1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ELISA, IP에 적합합니다. 인간 및 생쥐 시료에 반응하며, 액상 형태로 제공됩니다. 신경세포 발달 및 축삭 성장 연구에 활용 가능합니다.
- 카탈로그번호
- CRMP1-101AP
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 80–130 of CRMP1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) containing 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and olfactory system suggests involvement in adult brain plasticity.
CRMP-1 was initially identified as a dihydropyrimidinase expressed exclusively in the brain; later studies have shown its role in neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization shifts from axonal to somatodendritic as neurons mature, indicating its function in early neuronal differentiation and in processes related to neuronal survival or death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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