Thermo Fisher Scientific DcR1 Recombinant Rabbit Monoclonal Antibody (6M5C5)
Recombinant rabbit monoclonal antibody (clone 6M5C5) specific for human DcR1/CD263. Validated for Western blot and ELISA. Expressed in HEK293 cells and purified by Protein A. Supplied in PBS with BSA and glycerol for stable storage at -20°C.
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific DcR1 Recombinant Rabbit Monoclonal Antibody (6M5C5)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6M5C5 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 26–235 of human DcR1/CD263 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.19 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
ATTARQEEVP QQTVAPQQQR HSFKGEECPA GSHRSEHTGA CNPCTEGVDY TNASNNEPSC FPCTVCKSDQ KHKSSCTMTR DTVCQCKEGT FRNENSPEMC RKCSRCPSGE VQVSNCTSWD DIQCVEEFGA NATVETPAAE ETMNTSPGTP APAAEETMNT SPGTPAPAAE ETMTTSPGTP APAAEETMTT SPGTPAPAAE ETMITSPGTP
Target Information
TRAIL-R3 (CD263) is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. It functions as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. The gene is p53-regulated and DNA damage-inducible, expressed in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to TRAIL-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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