Thermo Fisher Scientific CCDC134 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CCDC134. Recombinant protein control fragment (Product #RP-91496). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CCDC134,uniProtId:Q9H6E4-1,ncbiNodeId:9606,antigenRange:47-169,antigenLength:229,antigenImageFileName:PA5-52029_CCDC134_Q9H6E4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52029_CCDC134_Q9H6E4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639383

Product Specific Information

Immunogen sequence: LLALKNLAQL NDIHQQYKIL DVMLKGLFKV LEDSRTVLTA ADVLPDGPFP QDEKLKDAFS HVVENTAFFG DVVLRFPRIV HYYFDHNSNW NLLIRWGISF CNQTGVFNQG PHSPILSLMA QEL

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 95%.

Target Information

The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. One such protein is CCDC134, a recently identified secretory protein that has been found to inhibit the transcriptional activity of the Elk1 protein. Overexpression CCDC134 also inhibited the phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while specific siRNA against CCDC134 activated Elk1 transcriptional activity and the phosphorylation of Erk and JNK/SAPK, suggesting a potential inhibiting role of CCDC134 in MAPK-mediated Elk1 transcription. CCDC134 is widely expressing in normal adult tissues, tumors, and cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.