Thermo Fisher Scientific beta Tubulin Polyclonal Antibody
Thermo Fisher Scientific의 beta Tubulin Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 고품질 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 신경세포 및 세포골격 연구에 활용됩니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 안정적인 저장 및 재현성 높은 결과를 제공합니다.
- 카탈로그번호
- PA521826
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment containing a sequence corresponding to amino acids 174–428 (Q9H4B7) of beta Tubulin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11156637 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, NIH-3T3
- Predicted reactivity: Mouse (92%), Cat (81%), Pig (90%), Chicken (86%), Bovine (93%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules.
Beta-III tubulin is primarily expressed in neurons and may play roles in neurogenesis, axon guidance, and maintenance. Mutations in the beta tubulin gene cause congenital fibrosis of the extraocular muscles type 3.
Beta-III tubulin is also detected in Sertoli cells and transiently in non-neuronal embryonic tissues.
Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression, affecting incorporation into microtubules.
Microtubules, composed of alpha and beta tubulin dimers (~55 kDa each), are essential for mitosis, intracellular transport, ciliary movement, and cytoskeletal structure.
Beta-tubulin is widely used as a loading control in protein detection assays such as Western blotting.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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