Thermo Fisher Scientific MORF Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total MYST4.

Target Information

MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations identified in a subtype of acute myeloid leukemias, resulting in MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, leading to enhanced transcriptional activation through aberrant histone acetylation.

Additional MOZ-related proteins, including MORF (MOZ related factor) and Tip60 (TAT interacting protein 60), share significant similarities with MOZ, including the putative HAT domain. MORF contains a strong transcriptional repression domain at its N terminus and a potent activation domain at its C terminus, suggesting dual functions in transcriptional regulation. Tip60 acts as a coactivator for the HIV TAT protein and as a nuclear hormone receptor coactivator enhancing ligand-dependent transactivation involving androgen, estrogen, and progesterone receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-103344_MORF_Q8WYB5-1_Rabbit.svg, PA5-103344_MORF_Q8WYB5-1_Rabbit_PDP.jpeg)