Thermo Fisher Scientific MTM1 Polyclonal Antibody
Thermo Fisher Scientific의 MTM1 Polyclonal Antibody는 Human MTM1 단백질을 타깃으로 하는 Rabbit IgG 항체입니다. Western blot 및 IHC(P) 검증 완료, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며, 안정적인 저장 및 다양한 응용에 적합합니다.
- 카탈로그번호
- PA552725
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MTM1. Recombinant protein control fragment (Product # RP-92237) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644270 |
Product Specific Information
Immunogen sequence:
LDHLYSCRFG TFLFNCESAR ERQKVTERTV SLWSLINSNK EKFKNPFYTK EINRVLYPVA SMRHLELWVN YYIRWNPRIK QQQPNPVEQR YMELLALRDE YIKRLEELQL ANSAKLSDPP TSPSSPSQMM P
Highest antigen sequence identity to the following orthologs:
- Mouse: 92%
- Rat: 55%
Target Information
Human MTM1 is a 603 amino acid protein mutated in myotubular myopathy. The related protein hMTMR2 is mutated in a recessive form of Charcot-Marie-Tooth neuropathy. Myotubularin functions as a lipid phosphatase acting on phosphatidylinositol 3-monophosphate and plays a role in the regulation of the PI 3-kinase pathway and membrane trafficking. Wild-type myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro, reducing PI 3-P levels by down-regulating PI 3-K activity and promoting PI 3-P degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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