Thermo Fisher Scientific GTPBP2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive control: 293T cells
• Predicted reactivity: Mouse (99%), Rat (100%), Zebrafish (87%), Xenopus laevis (94%), Rhesus Monkey (100%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Small G proteins act as molecular switches regulating various cellular processes such as nuclear transport, signal transduction, membrane trafficking, and protein synthesis.
GTPBP2 (GTP-binding protein 2) is a 602-amino-acid G protein expressed in kidney, skeletal muscle, testis, brain, and thymus, but not in liver. Expression is enhanced by γ-interferon stimulation in HeLa, THP-1, and thioglycollate-elicited mouse peritoneal macrophages.
There are four isoforms of GTPBP2 resulting from alternative splicing. GTPBP2 shares 44% sequence similarity with GTPBP1 and overlaps in expression pattern, suggesting possible genetic compensation for GTPBP1 deficiencies.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.