Thermo Fisher Scientific ZNRF2 Polyclonal Antibody
ZNRF2 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 유래 합성 펩타이드 기반으로 제작됨. ICC/IF에 사용 가능하며 1:100–1:500 희석 권장. E3 유비퀴틴-단백질 리가아제 연구에 적합. 1 mg/mL 농도의 액상 형태로 -20°C 보관.
- 판매단위
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Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human ZNRF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2555748 |
Target Information
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s), and the ubiquitin-protein ligases (E3s).
ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, endosome, and cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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