Thermo Fisher Scientific APIP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
MSGCDAREGD CCSRRCGAQD KEHPRYLIPE LCKQFYHLGW VTGTGGGISL KHGDEIYIAP SGVQKERIQP EDMFVC

Target Information

The mammalian homologues of the key cell death gene CED-4 in C. elegans have been identified recently from human and mouse and designated Apaf 1 (for apoptosis protease-activating factor 1). Apaf 1 binds to cytochrome c (Apaf 2) and Caspase-9 (Apaf 3), which leads to Caspase-9 activation. Activated Caspase-9 in turn cleaves and activates Caspase-3, responsible for proteolytic cleavage of many key proteins in apoptosis.

Recently, Cho et al. identified a new Apaf 1 interacting protein (APIP), also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1. APIP encodes a 204 amino acid protein. An isoform, APIP2, encodes a 242 amino acid protein differing in its N-terminus due to alternative splicing. APIP transcript is ubiquitously expressed in most adult tissues with high expression in skeletal muscle, heart, and kidney.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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