Thermo Fisher Scientific APIP Polyclonal Antibody
Thermo Fisher Scientific의 APIP Polyclonal Antibody는 인간 APIP 단백질을 인식하는 토끼 다클론 항체입니다. Western blot 및 IHC(P) 검증 완료. 고순도 항원 친화 크로마토그래피로 정제되었으며, 연구용으로 안정적인 장기 보관이 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human APIP. Recombinant protein control fragment (Product #RP-92053). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789905 |
Product Specific Information
Immunogen sequence:
MSGCDAREGD CCSRRCGAQD KEHPRYLIPE LCKQFYHLGW VTGTGGGISL KHGDEIYIAP SGVQKERIQP EDMFVC
Target Information
The mammalian homologues of the key cell death gene CED-4 in C. elegans have been identified recently from human and mouse and designated Apaf 1 (for apoptosis protease-activating factor 1). Apaf 1 binds to cytochrome c (Apaf 2) and Caspase-9 (Apaf 3), which leads to Caspase-9 activation. Activated Caspase-9 in turn cleaves and activates Caspase-3, responsible for proteolytic cleavage of many key proteins in apoptosis.
Recently, Cho et al. identified a new Apaf 1 interacting protein (APIP), also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1. APIP encodes a 204 amino acid protein. An isoform, APIP2, encodes a 242 amino acid protein differing in its N-terminus due to alternative splicing. APIP transcript is ubiquitously expressed in most adult tissues with high expression in skeletal muscle, heart, and kidney.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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