Thermo Fisher Scientific GRB10 Monoclonal Antibody (OTI6G1), TrueMAB
Human GRB10 단백질(aa 164-415)을 항원으로 한 Mouse IgG1 단클론 항체. Western blot에 1:500 희석으로 검증됨. 액상 형태, PBS/BSA/glycerol buffer에 보존. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6G1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 164–415 of human GRB10 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus.
A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7.
GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly.
GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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