Thermo Fisher Scientific GBP1 Monoclonal Antibody (OTI1B2)
인간 GBP1 단백질을 인식하는 마우스 단클론 항체로, 다양한 면역실험(WB, IHC, ICC, Flow)에 적합합니다. 고순도 친화크로마토그래피 정제, 액상 형태로 제공되며 안정적 저장용 PBS 버퍼 포함. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B2 |
| Immunogen | Full length human recombinant GBP1 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724346 |
Target Information
GBP1 (Guanlyate Binding Protein 1) is a 68 kDa GTPase belonging to the GTPase1 family. Its expression is induced by interferon-γ and inflammatory cytokines such as IL-1α, IL-1β, and TNF-α. GBP1 induction by poly I:C and dependency on NF-κB and IFNα response elements suggest involvement in TLR signaling pathways. GBP1 inversely correlates with MMP-1 expression and other molecules related to adhesion and migration, indicating its functional role in suppressing angiogenesis and cell migration, particularly in endothelial cells. As a regulatory molecule, GBP1 plays a central role in inflammatory signal transduction and cell migration networks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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