Thermo Fisher Scientific IVNS1ABP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7
• Predicted reactivity: Mouse (97%), Rat (97%), Pig (95%), Rhesus Monkey (100%), Bovine (95%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

IVNS1ABP is a protein-coding gene involved in various cellular processes including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination. It stabilizes actin filaments by associating with F-actin through Kelch repeats and protects cells from actin destabilization-induced death. IVNS1ABP modulates the AHR pathway by increasing AHR availability for transcriptional activation and acts as a negative regulator of the BCR(KLHL20) E3 ubiquitin ligase complex, preventing degradation of tumor suppressors PML and DAPK1. It also inhibits pre-mRNA splicing in vitro. During microbial infection, it participates in alternative splicing of influenza A virus M1 mRNA by interacting with HNRNPK, promoting generation of viral M2 protein.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.