Thermo Fisher Scientific NR3C2 Polyclonal Antibody
NR3C2 단백항체로 인간, 생쥐, 랫트 시료에 반응하며 Western blot, IHC, ICC/IF, ELISA 등에 적합합니다. Rabbit IgG 폴리클로날 항체로 고순도(1.32 mg/mL) 액상 형태이며, PBS/glycerol 저장 버퍼를 사용합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific NR3C2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 450–600 of human Mineralocorticoid receptor (NR3C2) (NP_0008922) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.32 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901620 |
Product Specific Information
- Positive Samples: HeLa, 293T, Mouse liver, Mouse kidney, Rat liver
- Immunogen Sequence:
FPFMDGSYFS FMDDKDYYSL SGILGPPVPG FDGNCEGSGF PVGIKQEPDD GSYYPEASIP SSAIVGVNSG GQSFHYRIGA QGTISLSRSA RDQSFQHLSS FPPVNTLVES WKSHGDLSSR RSDGYPVLEY IPENVSSSTL RSVSTGSSRP S
Target Information
Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone.
Mineralocorticoids are a family of steroids secreted by the adrenal cortex, necessary for the regulation of metabolic processes including electrolyte balance.
They exert their effect through interaction with the mineralocorticoid receptor (MR) and subsequent association with DNA.
The kidney is a primary target organ for mineralocorticoids, containing abundant MR.
The corresponding gene for the mineralocorticoid receptor is NR3C2.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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