Thermo Fisher Scientific TRIM56 Monoclonal Antibody (OTI8E12)
TRIM56 단백질을 인식하는 Mouse monoclonal 항체로 Western blot 및 IHC(P)에서 사용 가능. 인간 시료 반응성. Affinity chromatography로 정제된 액상 포맷. 항바이러스 면역 관련 단백질 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8E12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 311–554 of TRIM56 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725574 |
Target Information
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), it targets STING1 to Lys-63-linked ubiquitination, promoting its homodimerization, a step required for the production of type I interferon IFN-beta.
Independently of its E3 ubiquitin ligase activity, it acts as a positive regulator of TLR3 signaling, potentiating extracellular double-stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL, and CCL5/RANTES.
Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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