Thermo Fisher Scientific ATP6V0A1 Polyclonal Antibody

Thermo Fisher Scientific ATP6V0A1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100% | Dog: 100% | Guinea Pig: 100% | Horse: 100% | Human: 100% | Mouse: 100% | Rabbit: 100% | Rat: 100% | Zebrafish: 100%

Target Information

ATP6V0A1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.
V-ATPase dependent organelle acidification is necessary for intracellular processes such as:

• Protein sorting
• Zymogen activation
• Receptor-mediated endocytosis
• Synaptic vesicle proton gradient generation

V-ATPase is composed of:

• V1 domain (cytosolic): three A and three B subunits, two G subunits, plus C, D, E, F, and H subunits (contains ATP catalytic site)
• V0 domain (transmembrane): five different subunits — a, c, c′, c″, and d

Additional isoforms of many V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants.
This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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