Thermo Fisher Scientific Phospho-P53 (Thr81) Polyclonal Antibody

Thermo Fisher Scientific Phospho-P53 (Thr81) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or pyrimidine nucleotide starvation. p53 upregulation leads to transcription of genes such as p21waf1, contributing to G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain.

Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 also relates to aging, oxidative stress, and cognitive functions such as learning and memory. Normally expressed at low levels, p53 is highly expressed in transformed cells, contributing to malignancy. Mutations in TP53 disrupt DNA binding and tumor suppressor activity, occurring as somatic or germline mutations (e.g., Li-Fraumeni syndrome).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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