Thermo Fisher Scientific NXF3 Polyclonal Antibody
Human NXF3 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 고농도(0.95 mg/mL)로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific NXF3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 292–524 of Human NXF3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.95 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548174 |
Product Specific Information
- Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7
- Predicted reactivity: Chimpanzee (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family include:
- Noncanonical RNP-type RNA-binding domain (RBD)
- Four leucine-rich repeats (LRRs)
- Nuclear transport factor 2 (NTF2)-like domain enabling heterodimerization with NXT1
- Ubiquitin-associated domain mediating interactions with nucleoporins
The LRRs and NTF2-like domains are required for export activity. Alternative splicing is common in this gene family. The encoded protein has shortened LRR and ubiquitin-associated domains, and its RBD is unable to bind RNA. It is located in the nucleoplasm but not associated with the nuclear envelope or nucleolus.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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