Thermo Fisher Scientific PRMT9 Polyclonal Antibody
PRMT9 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western Blot에 적합하며, 고순도 Protein A 및 Antigen affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 39–68 amino acids from the N-terminal region of human PRMT10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634398 |
Target Information
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1.
The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in germinal center B-cells terminal differentiation toward memory B-cells and plasma cells.
It also mediates ubiquitination and degradation of DTL, an important step for regulation of TGF-beta signaling, cell migration, and timing of cell-cycle progression and exit.
Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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