Thermo Fisher Scientific TNFAIP8 Monoclonal Antibody (OTI1H9)
TNFAIP8 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 IHC(Paraffin)에서 검증됨. 인간 TNFAIP8 전체 길이 재조합 단백질을 면역원으로 사용. 액상 형태로 제공되며, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H9 |
| Immunogen | Full length human recombinant protein of TNFAIP8 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725538 |
Target Information
TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF.
The induction of TNFalpha-IP 8 by TNF is dependent on NFkappa B activation.
TNFalpha-IP 8 negatively mediates apoptosis and may play a role in tumor progression.
It specifically inhibits caspase-8 activity, preventing BID cleavage and caspase-3 activation during TNF-mediated apoptosis.
TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta, and various tumor tissues, as well as fetal lung, liver, and kidney.
Three isoforms are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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