Thermo Fisher Scientific PRDX2 Polyclonal Antibody
Thermo Fisher Scientific의 PRDX2 Polyclonal Antibody는 인간 및 랫트에 반응하는 고품질 항체로, Western blot, IHC, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관됩니다. 세포 분화 및 아폽토시스 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Peroxiredoxin 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792251 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (93%), Rat (93%), Pig (94%), Sheep (92%), Rhesus Monkey (100%), Bovine (91%).
- Positive Control: A549, HCT116.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family associated with cell proliferation, differentiation, and apoptosis.
Mammalian Prx proteins (approximately 50 isoforms) are classified based on amino acid sequence homology, particularly in the amino-terminal region containing the active site cysteine residue.
They exhibit thiol-specific antioxidant activity and are distributed across all kingdoms of life.
Mammalian Prx consists of six different members grouped into:
- Typical 2-Cys Prx
- Atypical 2-Cys Prx
- 1-Cys Prx
Except for Prx VI (1-Cys subgroup), the other five 2-Cys Prx isoforms possess thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system.
Mammalian Prxs are 20–30 kDa in molecular size and vary in subcellular localization:
- Prx I, II, VI: Cytosol
- Prx III: Mitochondria
- Prx IV: Endoplasmic Reticulum and secretion
- Prx V: Complex distribution including peroxisome, mitochondria, and cytosol
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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