Thermo Fisher Scientific PPP2R1B Monoclonal Antibody (OTI8B6)
PPP2R1B 단백질을 표적하는 mouse monoclonal antibody로 Western blot 및 IHC(P)에서 사용 가능. Human 시료에 반응하며, 고순도 Affinity Chromatography로 정제됨. 안정적인 액상 형태로 제공되며 -20°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8B6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19–601 of PPP2R1B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725094 |
Target Information
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis, and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases.
In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified: PP1, PP2A, PP2B (calcineurin), and PP2C. An additional catalytic subunit, PPX (also known as PP4), is a putative member of a novel PP family.
The PP2A family comprises subfamily members PP2A alpha and PP2A beta. The PP2A catalytic subunit associates with a variety of regulatory subunits, including PP2A-A alpha and -A beta, PP2A-B alpha and -B beta, PP2A-C alpha and -C beta, and PP2A-B56 alpha and -B56 beta.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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