Thermo Fisher Scientific TACC3 Monoclonal Antibody (OTI1E4), TrueMAB
인간 TACC3 단백질을 인식하는 마우스 단클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. 고순도 친화 크로마토그래피 정제, 보존제 무첨가. -20°C에서 보관하며 재구성 및 결합 실험에 적합.
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Thermo Fisher Scientific TACC3 Monoclonal Antibody (OTI1E4), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E4 |
| Immunogen | Full length human recombinant protein of human TACC3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TACC1 is located on the 8p11 chromosomal region, amplified in approximately 15% of breast tumor samples. The short arm of chromosome 8 also contains FGFR1, which is overexpressed in many breast cancer tumors.
TACC family members (TACC1, TACC2, TACC3) are closely mapped to FGFR1, FGFR2, and FGFR3 genes on chromosomes 4, 8, and 10, respectively. Since they are phylogenetically related, TACC and FGFR are proposed to have similar roles in cell growth and differentiation.
TACC1 contains a conserved C-terminal region similar to the Drosophila homolog D-TACC, which is essential for normal spindle function. Mammalian TACC proteins appear to interact with centrosomes and microtubules in a similar manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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