Thermo Fisher Scientific AKAP12 Polyclonal Antibody
AKAP12 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. 인간 시료 반응성이 있으며, 항원 친화 크로마토그래피로 정제된 고순도 제품입니다. 신호전달 관련 연구용으로 권장됩니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the C-terminal of human A kinase (PRKA) anchor protein 12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2636029 |
Product Specific Information
This antibody detects endogenous levels of total AKAP12 protein.
Target Information
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that bind to the regulatory subunit of protein kinase A (PKA) and localize the holoenzyme to discrete cellular regions.
AKAP12 is expressed in endothelial cells, fibroblasts, and osteosarcoma cells, acting as a scaffold for protein kinases A and C and phosphatases in signal transduction.
It colocalizes with RII PKA at the cell periphery and is associated with cell growth regulation.
Antibodies to AKAP12 may occur in patients with myasthenia gravis.
Alternative splicing produces two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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